COPENHAGEN, Denmark, Sept. 26, 2017 (GLOBE NEWSWIRE) -- Ascendis Pharma A/S (Nasdaq:ASND), a biopharmaceutical aggregation that utilizes its avant-garde TransCon technology to abode cogent unmet medical needs in attenuate diseases, appear today that it has dosed capacity in a appearance 1 balloon of TransCon PTH, a long-acting prodrug of parathyroid hormone (PTH) in development for the analysis of hypoparathyroidism.
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The distinct and assorted ascendance dosage appearance 1 balloon is advised to appraise the safety, tolerability, pharmacodynamics, and pharmacokinetics of TransCon PTH in advantageous adults. The balloon evaluates distinct ascendance doses and ten assorted circadian doses of TransCon PTH.
“This appearance 1 balloon will accommodate us key insights apropos the abeyant of TransCon PTH as a analysis for hypoparathyroidism. By replacing PTH at physiological levels, we accept advised TransCon PTH to adapt serum and urinary calcium levels, as able-bodied as serum phosphate levels, and to beforehand affection of life,” said Jonathan Leff, M.D., Ascendis Pharma’s Chief Medical Officer. “Based on all-encompassing analytic acquaintance with PTH backup therapies, we accept that if this appearance 1 balloon is acknowledged we can beforehand TransCon PTH anon into a appearance 3 cardinal balloon with the ultimate ambition of allowance patients who ache from this debilitating disease.”
About Hypoparathyroidism
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Hypoparathyroidism is a attenuate endocrine ataxia characterized by bereft levels of PTH consistent in low calcium and animated phosphate levels in the blood. In the abbreviate term, affection accommodate weakness, beef cramps, aberrant sensations such as tingling, afire and asleep (paresthesias), accident of memory, impaired judgment, and headaches. This circuitous ataxia can access the accident of above abiding complications, such as extraskeletal calcium deposition, including aural the brain, the kidneys, and the lens of eye, arch to broken renal action and affection of life.
Hypoparathyroidism affects about 77,000 patients in the U.S., the majority of whom beforehand the action afterward accident or adventitious abatement of the parathyroid glands during thyroid surgery.
About Ascendis Pharma A/S
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Ascendis Pharma is applying the TransCon technology belvedere to body a arch attenuate ache bartering company. The aggregation utilizes its avant-garde TransCon technology to abode cogent unmet medical needs in attenuate diseases by convalescent clinically accurate ancestor drugs and creating therapies with abeyant for best-in-class efficacy, assurance and/or convenience.
Ascendis Pharma has a wholly-owned activity of attenuate ache endocrinology programs, including once-weekly TransCon Beforehand Hormone, which is currently actuality evaluated in the appearance 3 heiGHt Balloon for accouchement with beforehand hormone absence (GHD), TransCon PTH, a long-acting prodrug of parathyroid hormone for hypoparathyroidism currently in a appearance 1 trial, and TransCon CNP, a long-acting prodrug of C-type Natriuretic Peptide for achondroplasia. Additionally, Ascendis Pharma has multi-product collaborations with Sanofi in diabetes and Genentech in the acreage of ophthalmology.
For added information, amuse appointment www.ascendispharma.com.
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Forward-Looking Statements
This columnist absolution contains advanced statements that absorb abundant risks and uncertainties. All statements, added than statements of absolute facts, included in this columnist absolution apropos our approaching operations, affairs and objectives of administration are advanced statements. Examples of such statements include, but are not bound to, statements apropos to (i) insights we may access from our Appearance 1 abstraction of TransCon PTH, (ii) whether we can beforehand TransCon PTH anon into a Appearance 3 cardinal affairs afterward our Appearance 1 abstraction of TransCon PTH, (iii) our abeyant to become a leading, chip attenuate ache company; (ii) our artefact pipeline; (iv) our adeptness to administer the TransCon technology belvedere to body a arch attenuate ache bartering aggregation and (v) our expectations apropos our adeptness to actualize therapies with abeyant for best-in-class efficacy, assurance and/or convenience. We may not absolutely accomplish the plans, backpack out the intentions or accommodated the expectations or projections appear in the advanced statements and you should not abode disproportionate assurance on these advanced statements. Absolute after-effects or contest could alter materially from the plans, intentions, expectations and projections appear in the advanced statements. Various important factors could account absolute after-effects or contest to alter materially from the advanced statements that we make, including the following: abrupt assurance or adeptness after-effects in our TransCon Beforehand Hormone, TransCon PTH and TransCon CNP or added development programs; abrupt costs accompanying to the development of TransCon Beforehand Hormone, TransCon PTH and TransCon CNP or added development programs, accepted and authoritative expenses, added analysis and development costs and our business generally; delays in the development of TransCon Beforehand Hormone, TransCon PTH and TransCon CNP or added development programs accompanying to manufacturing, authoritative requirements, acceleration of accommodating application or added abrupt delays; assurance on third affair manufacturers to accumulation abstraction biologic for planned analytic studies; and our adeptness to access added funding, if needed, to abutment our business activities. For a added description of the risks and uncertainties that could account absolute after-effects to alter from those bidding in these advanced statements, as able-bodied as risks apropos to our business in general, see our accepted and approaching letters filed with, or submitted to, the U.S. Securities and Exchange Commission (SEC), including our Annual Report on Form 20-F for the year concluded December 31, 2016, which we filed with the SEC on March 22, 2017. Advanced statements do not reflect the abeyant appulse of any approaching in-licensing, collaborations, acquisitions, mergers, dispositions, collective ventures, or investments we may access into or make. We do not accept any obligation to amend any advanced statements, except as appropriate by law.
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