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People who say their lives accept been broke by frequently assigned antidepressants, accepted as SSRIs, are demography their case to Parliament on Wednesday. Some users say the tablets accept fabricated them suicidal.
"I was accepting seizure-like symptoms, area my anatomy were blow about of their own accord," Claire Hanley tells the BBC's Victoria Derbyshire programme, answer the furnishings she says antidepressants had on her body.
She had amorphous demography them while caring for her actively ill mother and belief for her final exams at Cambridge University, but suffered astringent side-effects afterwards her GP assigned a stronger dosage of tablet.
"Within two weeks I'd approved to booty my own activity twice," she says.
"I acquainted disorientated and ailing and had digestive problems and infections, it was absolutely extreme. I don't alike apperceive how to begin. All I can bethink is actuality on the bedchamber attic in a affectionate of semi-conscious accompaniment accepting access afterwards massive seizure."
It has been 20 years aback she aboriginal took the tablets, but Ms Hanley says she still suffers from the after-effects of a cocktail of drugs doctors accept assigned to try to amusement the side-effects of the aboriginal antidepressants.
She says she has connected beef anguish and fatigue, and spends best canicule in bed.
The Victoria Derbyshire programme is advertisement on weekdays amid 09:00 and 11:00 on BBC Two and the BBC News channel.
It is anticipation about one in 100 bodies adventures astringent side-effects as a aftereffect of demography SSRIs.
The drugs are advised to access serotonin levels in the brain, which can advance affection of depression.
Some experts, however, now accept abounding added bodies than was ahead anticipation are adversity abrogating consequences.
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Prof David Healy, from the psychiatric assemblage at Bangor University, believes the drugs accomplish "one in four bodies become added anxious, rather than less".
"Some bodies become actual agitated and some go on from that to become suicidal," he says.
"The drugs can become the botheration that they're afresh acclimated to treat."
The drugs companies accept beneath to comment, but Dr Sarah Jarvis, a GP in West London, is agog to point out that doctors do not appoint antidepressants lightly.
She additionally stresses the basic role they can comedy in allowance bodies with abasement - saying, if untreated, "moderate abasement and astringent abasement bones lives, and actual consistently amount lives".
Dr Jarvis adds that for best people, the drugs are effective.
"I anticipate for bodies with astringent depression, they may charge to try two or three [different types of antidepressant] afore they acquisition one that does assignment for them, but for best bodies we can acquisition a anesthetic which will admonition them and for whom the allowances will outweigh the risks," she says.
Sources: Health and Social Care Information Centre, World Health Organization, NHS Choices
But according to some experts, such as Prof David Healy, the side-effects of antidepressants are not aloof acquainted aback addition is demography them, but additionally aback they try to abate the dosage or appear off the tablets altogether.
"There's a ample cardinal of bodies - and it seems to be added women than men - who accept abundant difficulties aggravating to abate the dose," he says.
"And if they arrest the treatment, they can become awfully agitated, they can become suicidal."
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"When you attending at the analytic trials that accept been done, the abate appearance - the point area the being is aggravating to appear off the biologic - is the riskiest period.
"That's the point area the being is best acceptable to accomplish suicide, or the best acceptable to do abhorrent things."
Gemma - not her absolute name - says her abandonment affection were so bad that she is now aback on the tablets.
"I was told I could appear off [antidepressants] no problem," she says.
"But I was in a blend basically. I accomplished a point area I could almost function. I was abundantly afraid - I was awful afraid all the time, so I was actual panicky, actual agitated. I could almost sleep."
Gemma had followed medical admonition and appear off the tablets slowly, but she suffered astringent after-effects nevertheless.
She says: "I was petrified. I was arrant my eyes out. I didn't apperceive what on Earth was accident to me. I estimated it could be the medication, but I anticipation I had some affectionate of terminal illness. I aloof didn't apperceive what was happening."
Gemma eventually absitively to go aback on the drugs, and the abandonment affection bound disappeared.
"I was shocked. All the migraines, the beef aches - aggregate - aloof chock-full instantly," she says.
Withdrawal affection usually action aural bristles canicule of endlessly the tablets, and about aftermost for up to six weeks.
Many bodies acquisition the furnishings manageable, but others - some of whom got in acquaintance with us - say they accept been acutely affected. Here are a few.
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Brigitte, from Exeter, said: "I couldn't airing and was experiencing the best abominable acoustic sensations. My anatomy were burning, I had facial twitches, abhorrent night sweats and asleep on my forehead."
Pauline, from Hertfordshire, said: "I attending and feel like a biologic addict, I can't focus my eyes. My eyes are like slits alike if I've not been crying. I cannot beddy-bye at all, and because it seems my anatomy realises it is not accepting the drug, every day is active hell."
Christine said: "The fatigue is so bad that I accept to go to bed in the afternoons and can do actual little. I feel dizzy, nauseous, accept blurred eyes and a cephalalgia at the aback of my arch and on top."
But others accept bodies who charge medication should not be put off by those who accept accomplished astringent symptoms.
Mehran, from south-east London, said: "I accept been on and off antidepressants for over a decade. It is alone accustomed to accept abandonment furnishings as the academician becomes adequate with a assertive akin of chemicals. Usually, those people, like myself, who withdrew abruptly absolutely still bare the medication. I anguish [that the belief of those with astringent symptoms] put abhorrence into the bodies that charge medication."
Mark, from London, said: "[When I started demography antidepressants] I did feel more, rather than less, afraid for the aboriginal two to three weeks - which was accompanied by beef twitches, abhorrence and a accepted activity of dissociation. But afresh I acquainted fine, I could action afresh and I got better. I accept SSRIs provided a accessory to abutment me through a difficult time, while I formed on award a longer-term band-aid application psychotherapy." Mark does not anamnesis experiencing any abandonment symptoms.
For Dr Jarvis, however, while some individuals may ache abiding side-effects from antidepressants - abiding months or, on occasion, years - she would be afraid if all of the appear furnishings accompanying to the tablets.
"What we charge to buck in apperception is that some patients who accept taken these accept been actual vulnerable, they've been actual afraid and it can be actual difficult to acquaint what is all-overs and what is the tablets," she says.
But for Ms Hanley, the dangers charge be taken added actively by medical professionals.
"It may be a boyhood of bodies who accept these acute reactions, but they exist," she says.
"If you attending at the leaflets in the packets, and it says one in 100 will accept this symptom, they've got to realise that that one being could be their patient. It does happen."
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