December 13, 2011
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Celgene International Sàrl, a accessory of Celgene Corporation (NASDAQ: CELG), today appear final after-effects from the appearance II allocation of a multi-center appearance I/II abstraction evaluating aggregate analysis with REVLIMID (lenalidomide) and VIDAZA (azacitidine) in patients with higher-risk myelodysplastic syndromes (MDS) not ahead advised with either drug. These abstracts were presented at the 53rd Annual Meeting of the American Society of Hematology in San Diego, CA.
At a average aftereffect of 15 months and a average of bristles cycles of therapy, the all-embracing acknowledgment amount for 35 evaluable patients was 72%, with 15 patients (42%) accomplishing a complete acknowledgment and 11 (28%) accomplishing hematologic improvement. Three patients had accelerating ache while on therapy. The average continuance of complete acknowledgment at aftermost abstraction appraisal was 16 months (range, 3-36) and average all-embracing adaptation for patients accomplishing a complete acknowledgment was 27 months (range, 7-55). Seven (50%) complete responders progressed to AML at a average of 20 months from accomplishing complete response.
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Grade 3/4 non-hematologic adverse contest (AEs) (related or unrelated) included cardiac (11%), delirious neutropenia (31%), added infection (8%), pulmonary (11%), vascular access-related occlusion (6%), CNS drain (6%) or added (11%). Three (8%) patients died while on study. Average decreases from baseline in complete neutrophil calculation (ANC) and platelets were 35% and 18%, respectively, aural the aboriginal eight weeks.
VIDAZA and REVLIMID are not an accustomed aggregate for analysis of patients with higher-risk MDS.
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Source:
Celgene International Sàrl
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