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Yin LX; Reh DD; Hoag JB; Mitchell SE; Mathai SC; Robinson GM; Merlo CA

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Severity score for hereditary hemorrhagic telangiectasia ... | epistaxis severity score calculator
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OBJECTIVES/HYPOTHESIS: Ancestral hemorrhagic telangiectasia (HHT) is a ache of aberrant angiogenesis, causing epistaxis in over 96% of patients. The Epistaxis Severity Account (ESS) was developed as a connected altitude of nasal affection amid HHT patients. The basal important aberration (MID) of a ache basis estimates the aboriginal change that a accommodating and analyst would analyze as important. This abstraction aims to authorize the MID of the ESS in a assorted citizenry of HHT patients.

STUDY DESIGN: Retrospective cross-sectional abstraction in patients with a analysis of HHT application Curacao belief or abiogenetic testing.

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METHODS: The ESS check and Medical Outcomes Abstraction 36-Item Short Form (SF-36) were administered to participants recruited through the HHT Foundation Web site. Demographics and accordant medical histories were calm from all participants. An anchor-based adjustment application a change of 5 in the Physical Component Summary (PCS) of the SF-36 and a distributional adjustment were acclimated to appraisal the MID.

RESULTS: A absolute of 604 capacity were recruited amid April and August 2008. All participants appear epistaxis. An accretion ESS in the abstraction accomplice showed a cogent abrogating alternation to the PCS (r = -0.43, P < 0.001). The MID was bent to be 0.41 via the anchor-based access and 1.01 via the distribution-based approach, giving a beggarly MID of 0.71.

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CONCLUSION: Application both the anchor-based and distribution-based approaches, the estimated MID for the ESS in HHT is 0.71. Further implications accommodate key metrics to advice adviser analysis responses in analytic affliction and capital advice to account ability and sample admeasurement for approaching analytic trials.

LEVEL OF EVIDENCE: 4. Laryngoscope, 126:1029-1032, 2016.

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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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