Genome-wide affiliation studies (GWASs) accept become the focus of the statistical assay of circuitous ancestry in humans, auspiciously address ablaze on several aspects of abiogenetic architectonics and biological aetiology. Single-nucleotide polymorphisms (SNPs) are usually modelled as accepting additive, accumulative and absolute furnishings on the phenotype. Although clearly a advantageous approach, it is generally argued that this is not a astute biological archetypal and that epistasis (that is, the statistical alternation amid SNPs) should be included. The purpose of this Review is to abridge contempo admonition in alignment for audition epistasis and to altercate affirmation of the role of epistasis in animal circuitous affection variation. We additionally altercate the appliance of epistasis in the ambience of GWASs and abeyant hazards in the estimation of statistical alternation terms.
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