September 18, 2009 (San Francisco, California) — A new abstraction shows that a accepted nasal aerosol ability accept an antiviral aftereffect adjoin rhinovirus and could possibly abate the accident for ache transmission, according to analysis presented actuality at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy.
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Topical Afrin or oxymetazoline for treatment of bloody noses | epistaxis oxymetazoline[/caption]
Oxymetazoline, an additive in over-the-counter nasal decongestant sprays, decidedly bargain virus titers in nasal secretions in capacity who had been inoculated with a rhinovirus.
"It's a actual absorbing effect, and it deserves added studies to assay how it can be used," advance columnist Birgit Winther, MD, advance columnist and accessory assistant of otolaryngology at the University of Virginia in Charlottesville, told Medscape Communicable Diseases.
Dr. Winther said the nasal aerosol ability advice in alleviative astringent colds by preventing intranasal overextension of the virus or by preventing advance to the sinuses or lungs. Dr. Winther and her adolescent authors additionally speculated that the aerosol could abatement broadcasting of the virus into the environment.
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Topical Afrin or oxymetazoline for treatment of bloody noses | epistaxis oxymetazoline[/caption]
In the study, 33 adulterated capacity accustomed 3 intranasal doses per day of .05% oxymetazoline hydrochloride adulterated in citric acid, and 37 others accustomed a acrid solution. The volunteers alternate anniversary day for 5 canicule so that the board could access nasal washes and appraise them for affection and adverse events. On days 6 and 7, there were no nasal washes taken, but volunteers were adjourned for affection and adverse events.
Results adumbrated that viral address occurred for 3.3 canicule in the oxymetazoline accumulation and 3.5 canicule in the acrid group. Mean viral titer in the oxymetazoline accumulation on day 2 was additionally decidedly lower than in the acrid accumulation (1.49 vs 2.24; P < 0.05).
"Usually amid day 2 and 3, you'll see a aiguille of virus in the nasal wash. That happened in the acrid group, but in the oxymetazoline accumulation we didn't see that peak. It remained flat," said Dr. Winther.
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Topical Afrin or oxymetazoline for treatment of bloody noses | epistaxis oxymetazoline[/caption]
Dr. Winther and her colleagues brainstorm that the aftereffect of oxymetazoline ability be due to its furnishings on ICAM-1 receptor expression. Several in vitro studies accept apparent that the biologic decreases ICAM-1 expression, she said.
An abstruse abstraction of 250 patients in Germany showed that the nasal aerosol beneath the continuance of colds in bodies with astringent symptoms, she said. In Dr. Winther's study, oxymetazoline additionally fabricated a aberration in appropriate illness. Of the those in the oxymetazoline group, 64% accomplished the Jackson belief for appropriate illness; of those in the acrid group, 76% did.
The amount of adverse contest in both groups was similar, Dr. Winther said. Adverse contest included cephalalgia and epistaxis.
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Topical Afrin or oxymetazoline for treatment of bloody noses | epistaxis oxymetazoline[/caption]
Dr. Winther acclaimed the limitations of the study. "This was not a blockage balloon or a analysis trial, but aloof a proof-of-concept to validate what we saw in analysis tubes," she said.
Other advisers acclaimed the study's baby size, which ability absolute the authority of its conclusions. "You additionally can't acquaint if the aftereffect was aloof coincidental, if it was due to the decongestant, or if the biologic absolutely acted to abolish the advance of the virus," Peter Katona, MD, accessory analytic assistant of communicable diseases at UCLA, told Medscape Communicable Diseases. "I'd appetite to see a lot added abstracts afore I came to the cessation that this is a acceptable affair to use," he added.
Although Dr. Winther is agog about the affiance of oxymetazoline, Dr. Katona charcoal skeptical. "I don't like this drug," he said. "The acumen is that bodies use it for congestion, and again they stop application it, and it gives them bottleneck that is far worse than the aboriginal symptoms."
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Topical Afrin or oxymetazoline for treatment of bloody noses | epistaxis oxymetazoline[/caption]
The abstraction was adjourned by Merck Selbastmedikation GmbH. Dr. Winther letters accepting analysis abutment from Merck Selbastmedikation GmbH. Dr. Katona appear no accordant banking relationships.
49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC): Abstract V-536. Presented September 13, 2009.
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